Dr. Christine Grady, head of the Department of Bioethics at the NIH Clinical Center, explained to Clinical Center Radio in a podcast that participants in research should make their own decision after being fully informed of the study's purpose, as well as its potential risks and benefits.

Clinical research improves human health and furthers scientific knowledge. Volunteers are an integral part of the study process, therefore it's crucial to keep them in mind. Researchers can ensure the safety of study participants by careful preparation, execution, and follow-up. In order to safeguard study participants and maintain confidence in the results, ethical standards have been developed for clinical trials.

Seven fundamental principles for doing ethical research were outlined by researchers at the NIH Clinical Center. Ethical Research: 

A Set of Principles
Benefits to society and medicine, No. 1.
Also, it has to hold up to the scientific method.
No bias in the choice of topics.
4 the reward to risk ratio is good.
5. An impartial evaluation.
6. Informed consent.
7. Honor for interested and participating participants.
 

Benefits to Society and Medicine
 

There is always a central inquiry that motivates a research project. The solution should be substantial enough to warrant asking individuals to put themselves in harm's way. Justifying the risk and cost of study requires that the answers to the research question advance our knowledge of health or increase our ability to prevent, treat, or care for individuals with a certain condition.
True scientific merit
It's crucial to design a study in a manner that yields a clear response to the central research question. The study's validity and feasibility, the research methodologies' validity and feasibility, and whether or not the study was created using established principles, clear procedures, and dependable practices are all things to think about. The immoral nature of invalid research lies in the fact that it wastes money and puts people in danger for no good reason.
Objects are chosen fairly
 

Participants should be recruited based on the research's scientific aims, not on their perceived vulnerability, level of privilege, or anything else irrelevant to the study. Risks and advantages of the study should be clearly communicated to all participants. There should be a valid scientific justification or a heightened vulnerability for excluding certain categories of participants (such as women or children) from study possibilities.
Positive benefit-risk analysis
There is always a degree of mystery surrounding the risks and potential rewards of participating in a clinical trial. Research hazards may be modest or substantial, transitory or long-term. Potential dangers might be of the physical, mental, financial, or social kind. In order to ensure that the advantages of the study exceed the risks involved, every effort must be made to reduce the possibility for harm to the participants.
Independent review, a review by a reviewer who has a
An impartial review panel should evaluate a research proposal and ask crucial questions like these before it begins to reduce the likelihood of conflicts of interest and ensure the study can proceed ethically. How unbiased are the people running the trial? Is every precaution being taken to ensure the safety of the participants? Is there a positive risk-benefit ratio, and has the experiment been structured ethically? The panel also keeps tabs on a research while it's being conducted.
 

Consent after being informed
 

Research participants have the right to choose whether or not they wish to take part in a study. Participants give their consent based on their understanding of the study's goals, procedures, risks, benefits, and alternatives as they relate to the participant's individual clinical situation or interests, as outlined in the study's informed consent document.
Considering the feelings of prospective and current members
People should be treated with dignity from the moment they are contacted about participating in a research (even if they decline enrolment) until long after they have finished taking part in the study. All of their personal information will be kept strictly secret, and they will be allowed to withdraw from the study at any time if they feel it is not for them.
Monitoring their health and providing appropriate treatment and, if necessary, removal from the study if they experience adverse reactions, unexpected effects, or changes in clinical status is essential, as is informing them of what was learned from the research and how it applies to their situation are also crucial.